Protein Details: P2X purinoceptor 2

Protein ID

ICDB_Pro_1264

Protein Name

P2X purinoceptor 2

Gene Name

P2rx2; P2x2

Organism

Mus musculus (Mouse)

Length

485 amino acids

AlphaFoldDB

AF-Q8K3P1-F1-model_v4.pdb

Function

ATP-gated nonselective transmembrane cation channel permeable to potassium; sodium and calcium (By similarity). Activation by extracellular ATP induces a variety of cellular responses; such as excitatory postsynaptic responses in sensory neurons; neuromuscular junctions (NMJ) formation; hearing; perception of taste and peristalsis. In the inner ear; regulates sound transduction and auditory neurotransmission; outer hair cell electromotility; inner ear gap junctions; and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle.

Sequence

MAAAQPRLPAGAAMVRRLARGCWSAFWDYETPKVIVVRNRRLGFVHRMVQLLILLYFVWYVFIVQKSYQDSETGPESSIITKVKGITMSEHKVWDVEEYVKPPEGGSVVSIITRIEVTPSQTLGTCPESMRVHSSTCHLDDDCVAGQLDMQGNGIRTGRCVPYYHGDSKTCEVSAWCPVEDGTSENHFLGKMAPNFTILIKNSIHYPKFKFSKGNIASQKSDYLKHCTFDQDSDPYCPIFRLGFIVEQAGENFTELAHKGGVIGVIINWNCDLDLSESECNPKYSFRRLDPKYDPASSGYNFRFAKYYKINGTTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSIGVGSFLCDWILLTFMNKNKLYSHKKFDKVRTPRHPSSRWPVTLALVLGQIPPPPSHYSQDQPPSLPSGEGPALGEGAELPLAVQPPRSCSSSALTEQVVDTLDQHMGQRPPVPEPSQQDSTSTDPKGLAQL

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 82; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 84; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 197; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 297; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 301; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 303; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 321; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"

Disease

Location

DOI ID

10.1124/mol.105.019802; 10.1126/science.1112014; 10.1371/journal.pbio.1000112; 10.1101/gr.2596504; 10.1523/jneurosci.23-19-07426.2003; 10.1113/jphysiol.2003.047944; 10.1523/jneurosci.23-36-11315.2003; 10.1113/jphysiol.2005.088435; 10.1126/science.1118435; 10.1016/j.neuroscience.2007.06.050; 10.1073/pnas.1222285110

RefSeq

NP_001158305.1 [Q8K3P1-2]; NP_001158306.1 [Q8K3P1-3]; NP_001297629.1 [Q8K3P1-5]; NP_001297630.1 [Q8K3P1-4]; NP_700449.2 [Q8K3P1-1]; XP_011247750.1 [Q8K3P1-4]